화학적 처리가 티타늄의 생체활성도에 미치는 영향

민관식; 안승근; 박찬운; 이민호

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화학적 처리가 티타늄의 생체활성도에 미치는 영향
Effect of chemical treatment on the bioactivity of titanium

대한치과보철학회지 2005년 43권 4호 p.562 ~ 571

민관식, 안승근, 박찬운, 이민호,

소속 상세정보

민관식 ( Min Kwan-Sik ) - 전북대학교 치과대학 치과보철학교실 및 구강생체과학연구소
안승근 ( Ahn Seung-Geun ) - 전북대학교 치과대학 치과보철학교실 및 구강생체과학연구소
박찬운 ( Park Charn-Woon ) - 전북대학교 치과대학 치과보철학교실 및 구강생체과학연구소
이민호 ( Lee Min-Ho ) - 전북대학교 치과대학 치과생체재료학교실

KMID : 0362420050430040562

Abstract

Statement of problem: Titanium is widely used as an implant material for artificial teeth. Also, studies on surface treatment to form a fine passive film on the surface of commercial titanium or its alloys and improving bioactivity with bone have been carried out. However, there is insufficient data about the biocompatibility of the implant materials in the body.

Purpose: The purpose of this study was to examine whether the precipitation of apatite on titanium metal is affected by surface modification.

Materials & Methods: Specimens chemically washed for 2 minute in a 1:1:1.5 (in vol%) mixture of 48% HF, 60% HNO3 and distilled water. Specimens were then chemically treated with a solution containing 97% H2SO4 and 30% H2O2 at 40 degrees C for 1 hour, and subsequently heat-treated at 400 degrees C for 1 hour. All specimens were immersed in the HBSS with pH 7.4 at 36.5 degrees C for 15 days, and the surface were examined with TF-XRD, SEM, EDX and XPS. Also, commercial purity Ti specimens with and without surface treatment were implanted in the abdominal connective tissue of mice for 4 weeks. Conventional aluminium and stainless steel 316L were also implanted for comparison

Results & Conclusion: The results obtained were summarized as follows. 1. An amorphous titania gel layer was formed on the titanium surface after the titanium specimen was treated with a H2SO4 and H2O2 solution. The average roughness was 2.175 micrometer after chemical surface treatment. 2. The amorphous titania was subsequently transformed into anatase by heat treatment at 400 degree C for 1 hour. 3. The average thickness of the fibrous capsule surrounding the specimens implanted in the connective tissue was 46.98 micrometer in chemically-treated Ti, and 52.20, 168.65 and 100.95 micrometer, respectively in commercial pure Ti, aluminum and stainless steel 316L without any treatment.